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NIH Undiagnosed Diseases Program Uncovers Its First New Genetic Disorder

first_imgNHGRI/NIH A National Institutes of Health (NIH) program aimed at tracking down the causes of mysterious diseases is bearing fruit. A multidisciplinary team of physicians and genetic researchers have discovered the genetic cause of a bizarre vascular disease afflicting two sisters that leads to a buildup of calcium in the arterial walls, causing joint hardening and pain. The group’s paper, published in tomorrow’s issue of The New England Journal of Medicine, is the first report of a new genetic disease to come out of NIH’s 3-year-old Undiagnosed Diseases Program. It’s a consortium of researchers from across NIH and volunteer experts from academic medical centers around the country who receive referrals for patients whom physicians have been unable to diagnose. “A success like this buoys us emotionally and encourages us,” program director and study co-author William Gahl, who is also clinical director of the National Human Genome Research Institute, said in a press conference Tuesday. Since its inception in 2008, the Undiagnosed Diseases Program has received 1700 referrals and accepted 330 of them; the researchers report seeing 150 to 200 patients per year. The program’s aim, Gahl said, is twofold: to diagnose patients whose diseases have eluded medical knowledge and to conduct research. Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*) In 2009, the program received a referral from a Kentucky doctor for two sisters, Paula Allen and Louise Benge, who suffered from joint pain and showed calcium buildup in their arteries in x-rays (above). The images “astounded us,” Gahl said. The team obtained DNA samples from the sisters and other family members (three of Allen and Benge’s siblings had the same recessive disease) and scanned the DNA for markers called single nucleotide polymorphisms that the researchers used to narrow the location of the disease gene. By also examining this genetic region in two other families with similar disorders, the researchers were able to pinpoint a mutation in a specific gene, NT5E, which is involved in breaking down calcification in the arteries. The researchers named the disease ACDC (arterial calcification due to CD73 deficiency). The discovery revealed a previously unknown molecular mechanism for preventing calcification and may open treatment avenues for patients suffering from the more common diseases of atherosclerosis and osteoporosis, said study senior author Manfred Boehm of NIH. Allen and Benge praised the “impressive” work by NIH. “Even if they can’t help us, maybe someday they can help someone else with these problems,” said Benge. Boehm said that a clinical trial for a drug to treat the sisters and others with ACDC is currently under review by an ethics board. The undiagnosed diseases program is “wonderful; … we were thrilled when it started,” said Mary Dunkle, spokesperson for the National Organization for Rare Diseases (NORD), a Washington, D.C.-based patient advocacy group. NORD has referred a number of patients to NIH. “In our world, a lot of times knowledge is gained in small increments,” Dunkle said. “It’s always progress when they’re able to identify something that’s a complete new entity.” *This item has been corrected 4 February to reflect that study co-author William Gahl is also the clinical director of the National Human Genome Research Institute.last_img read more

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Next few months very crucial says pacer Umesh

first_imgThe Indian domestic season begins on October 1 in Jaipur between the Rest of India (ROI) and Ranji champions Rajasthan. For a few players in the ROI squad, it is a golden chance to get into national reckoning, now that a major chunk of the Indian team is nursing serious injuries and would be out of action for some time.Among them, Vidarbha pacer Umesh Yadav is gearing up for what he feels is one of the most crucial phases for fast bowlers in India.Zaheer Khan has undergone surgery on his ankle and won’t be available for four months. Munaf Patel got injured in the final One-Day International (ODI) in England while Ishant Sharma, too, has a few niggles. With Sreesanth not in peak form, there are slots up for grabs in the pace department and Umesh knows now is the time to perform.”The next few months are very crucial for me. We all know that India needs fast bowlers now. So I am concentrating on doing my job correctly and the rest is up to the selectors,” Umesh told Mail Today on Tuesday.”The Irani Trophy match will be a perfect opportunity to make a mark. There are two series at home coming up and bowlers like me and Varun (Aaron) know that now is the time to up our game.” Both Umesh and Varun are regarded as the quickest bowlers in India right now, but both were made to warm the benches in two high- profile series this year. While Umesh didn’t get to play in the Test series in South Africa early this year, Varun didn’t play any of the five ODIs in England.advertisementBowling in helpful conditions would have been ideal for both, but Umesh doesn’t think it was a lost opportunity.”As a fast bowler, you can’t expect to bowl in pacy or seaming wickets most of the time. Most of the pitches will be pata (flat) and even in these countries (England and South Africa) you get flat wickets.So, one has to learn to bowl on batting tracks.” For the Irani match, the 23- year- old is expecting a wicket with not too much help for the pacers.”I don’t think Rajasthan would leave much grass on the wicket as they know our team has good quick bowlers. But since it is the start of the season, the wicket should have some freshness.”last_img read more

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Virender Sehwag mulls leaving Delhi for the upcoming domestic season

first_imgVirender Sehwag is “seriously considering” leaving the Delhi team for other state associations, which would open up opportunities for junior cricketers in his native domestic side.’ESPNcricinfo’ has reported that the former India opener is weighing offers from other state associations for the upcoming season.Sehwag is the most successful batsman from Delhi at the India level, scoring 17,000 plus runs across three formats. He has represented the Indian team in 104 Tests, 251 ODIs and 19 T20s.The 36-year-old had a productive Ranji Trophy last season, making 568 runs in eight games at an average of 51.63 and finishing only a run behind leading scorer Gautam Gambhir.He was less impressive in the 50-over tournament though, managing 131 runs in six matches at 21.83.Sehwag has been associated with Delhi ever since he made his first-class debut in 1997-98 season.Meanwhile, Mumbai veteran Wasim Jaffer is set to move base to Vidarbha.last_img read more

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2nd Test: Younis Khan hundred drives Pakistan against West Indies on Day 1

first_imgVeteran Younus Khan’s majestic century helped Pakistan dominate the opening day of the second Test against West Indies on Friday, the hosts reaching on 304/4 on a punishing day for the bowlers in Abu Dhabi. (Scorecard)The 38-year-old struck 10 fours and a six in his 127, finally out to the final ball of the day when he mistimed an attempted slog sweep off of Kraigg Brathwaite and was caught by Roston Chase in the deep.Bad light then ended play and the West Indies team sought the comfort of the dressing room after a chastening and sweaty day in the field.Hours earlier West Indies had actually made early inroads. (Pakistan’s Yasir Jan can bowl express pace with his left and right arms)Younus, who sat out the first test having only just recovered from a bout of dengue fever, came to the crease with Pakistan wobbling on 42/2 after Devendra Bishoo bowled opener Sami Aslam in the fifth over for six and Azhar Ali had chopped on to paceman Shannon Gabriel without troubling the scoreboard.Together with a fluent Asad Shafiq (68) he helped put on 87 for the third wicket before Shafiq attempted to cut a good length Gabriel delivery but only succeeded in diverting the ball down and on to his stumps.The punishment continued for the West Indian bowlers though as Misbah-ul-Haq and Younus set about them with relish.Pakistan reached the 200 mark just before tea and moved past the 300 mark in the 83rd over before the fourth-wicket partnership was ended at 175.advertisementYounus, struggled for timing early on but was commanding once he hit his stride, bringing up his 33rd Test century off his 169th ball when he cut Chase for a boundary.West Indies failed to exert any sort of control and were not helped by some slipshod fielding and several dropped catches that proved costly.Misbah-ul-Haq, who ended the day 90 not out, was put down when he was in the 50s after thick-edging edging Gabriel and Younus was also reprieved on 83 when Brathwaite failed to cling on to a relatively simple caught and bowled chance.Pakistan lead the series 1-0 after winning a thrilling first Test in Dubai by 56 runs.last_img read more

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Klopp: Palace win a massive relief

first_imgJurgen Klopp accepted it was a “massive relief” to see leaders Liverpool edge a thrilling Premier League clash with Crystal Palace 4-3 at Anfield.Liverpool were 1-0 down at half-time to Andros Townsend’s goal as Roy Hodgson’s Palace threatened to have another major impact on the title race following the Eagles’ win at Manchester City last month.A breathless start to the second half saw Mohamed Salah and Roberto Firmino capitalise on deflections before a James Tomkins header levelled the scores again. Article continues below Editors’ Picks Man Utd ready to spend big on Sancho and Haaland in January Who is Marcus Thuram? Lilian’s son who is top of the Bundesliga with Borussia Monchengladbach Brazil, beware! Messi and Argentina out for revenge after Copa controversy Best player in MLS? Zlatan wasn’t even the best player in LA! Salah’s 50th Premier League goal then came thanks to a woeful piece of goalkeeping by Julian Speroni and, after James Milner’s red card, Sadio Mane gave the Reds breathing space before Max Meyer’s injury-time consolation.It all added up to Liverpool moving seven points clear of champions City, who play at managerless Huddersfield Town on Sunday, with Klopp celebrating wildly at the full-time whistle.”It’s a massive relief,” the Liverpool manager said to BBC Sport. “We knew for different reasons the game would be difficult. Crystal Palace traditionally do well against Liverpool and with the physicality it was clear it would be like the first half was.”They are really good at counter-attacks and set-pieces, Wilfried Zaha is a world-class player and he gets into a one-on-one situation and we’re one down. We had to stay positive, being one down is not a massive blow, we just needed to win the second half and did what we had to do.”The result is massive, we have 60 points now it’s crazy, it’s an important number. I’m really proud, a few things happened that we don’t really need, we’re a bit short now on players but we have a few days and need to use the time now for recovery.”50 – Mo Salah has scored his 50th Premier League goal in his 72nd appearance in the competition – only Andy Cole (65), Alan Shearer (66) and Ruud van Nistelrooy (68) have reached the milestone in fewer appearances. Landmark. #LIVCRY pic.twitter.com/sEeA42GCjg— OptaJoe (@OptaJoe) January 19, 2019Salah’s brace means he reached 50 Premier League goals in his 72nd appearance, with only three players in the competition’s history having been faster to the milestone.”He’s world class,” Klopp said of the Egypt superstar. “Simply world class.”Salah himself insisted Liverpool deserved to take all three points, although he conceded allowing Palace to score three goals was far from ideal.”Honestly we expected a difficult game but they played well and they were compact in front of the box,” Salah said to Sky Sports. “In the end the most important thing is the result, conceding three goals is hard but we need to accept that and live with it.”We have to be strong mentally. This is a tough time for us and we have to talk and be strong. We played well today and deserved the game.” Subscribe to Goal’s Liverpool Correspondent Neil Jones’ weekly email bringing you the best Liverpool FC writing from around the weblast_img read more

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AIBA grants full membership to Boxing Federation of India

first_imgNew Delhi, Dec 20 (PTI) Indias return to the international boxing fold was complete today with the AIBA unanimously granting full membership to the recently-formed Boxing Federation of India (BFI) at a meeting on the sidelines of its 70th anniversary gala in Montreux, Switzerland. The BFI was voted to office in September earlier this year, ending four years of administrative logjam in the sport. “AIBA has voted unanimously to grant full membership to India,” BFI President Ajay Singh, who is currently in Montreux to take part in the AIBA event, told PTI. The BFI has already been granted affiliation by the Sports Ministry but is awaiting recognition from the Indian Olympic Association, which has referred the matter to an affiliation committee. Indian boxing was thrown into disarray back in 2012 when the erstwhile Indian Amateur Boxing Federation (IABF) was first suspended and later terminated for “possible manipulation in elections”. IABF paved the way for Boxing India in 2014 but the body could not run the show for even one year and lost a no confidence motion moved by disgruntled state units in 2015. After another year of wrangling, BFI took shape in September following elections conducted in the presence of observers from the International Boxing Association (AIBA) and the Sports Ministry. Since being voted in, the BFI has conducted the National Championships for both men and women and will be holding the Nationals for youth boxers next month. Indias international suspension for the past four years had resulted in the isolation of the countrys boxers, who were deprived of foreign exposure for most part. The lack of competitive boxing was a major factor in the boxers medal-less Olympic campaign in Rio after only three made the cut, a sharp decline from the eight who participated in the 2012 edition. But with AIBA formally recognising the new federation, the opportunities in international training-cum-competition events are set to increase for Indian boxers. PTI PM PDS PMadvertisementlast_img read more

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Transparency of Climate Finance: Results from Cancun and Next Steps

first_imgOpenClimateNetwork.orgVisit openclimatenetwork.org for the latest analysis, project info, expert perspectives, and more. The UNFCCC Cancun Agreements of December 2010 marked an important step forward for transparency of country actions to respond to climate change. In addition to creating a new standard for the way countries report on their national climate commitments and actions, the agreements mandated advances in the reporting and review of countries’ climate finance contributions.The success of Cancun in improving the transparency of climate finance will depend on the actions countries take to implement this mandate in the coming months, as there are still many details that need to be filled in. As countries meet in Bangkok this week, they will have to decide how to move forward on the details that were left up-in-the air in Cancun. The following questions help explain the issues on the table and the next steps.What is transparency of climate finance and why is it important?The 1992 United Nations Framework Convention on Climate Change (UNFCCC), agreed to by 195 countries, recognized that developed countries should provide new and additional financial, technology and capacity-building support to help developing countries reduce their greenhouse gas emissions and adapt to a changing climate. Accordingly, developed countries have committed to mobilizing $100 billion in climate change financing by 2020.Keeping track of these funds and ensuring that they are delivered effectively is a huge undertaking. In the world of international climate negotiations, the transparency of these climate finance arrangements — how governments, banks, international institutions and civil society groups report and review financial contributions –is referred to as the “measurement, reporting and verification” (MRV) of finance.Transparent and accurate reporting has many benefits. For example, developed countries can gain international recognition for their support and developing countries can gain assurance that the money pledged is actually delivered. Furthermore, increased transparency can help governments and civil society groups assess the scale and type of support provided, identify trends and pinpoint possible gaps in sectors or regions.Don’t countries already report their climate finance contributions?Yes, but existing systems need to be improved. Developed countries report their bilateral and multilateral climate finance contributions in periodic national communications submitted to the UNFCCC. However, countries currently use multiple methods for reporting and often provide insufficient information even where requested. Because of this, the data gathered are of limited utility.Outside the UNFCCC, developed countries report their overall development assistance to the OECD DAC and indicate which supported projects aim to help mitigate climate change. However, this framework has certain limitations. For example, development assistance supporting mitigation is measured in a qualitative rather than quantitative way, making it difficult to aggregate and analyze information. In addition, the mitigation category is applied to an entire project even if only a portion of the project relates to climate change.Do the Cancun Agreements improve MRV systems for long-term financial commitments?The Cancun Agreements mandate the revision and improvement of climate finance MRV, which could help alleviate some of the current limitations of reporting under the UNFCCC.Specifically, they call for enhanced reporting in national communications by developed countries. Enhanced reporting should include “common reporting formats” and “methodologies for finance”, to be developed, and should “ensure that information provided is complete, comparable, transparent and accurate.” Developed countries will also need to generate biennial reports that include information on progress in providing financial, technology and capacity-building support to developing countries.In addition to enhanced reporting of financial information, the COP called for enhanced review of this information.The Cancun Agreements also call for developing countries to submit national communications every four years, in which they must report on “support received.” This information could help reviewers cross-check information from developed countries.What about the transparency of the so-called ‘fast-start finance’?The Cancun Agreements invite developed countries to annually report their financial commitments to 2012 (known as “fast-start”). Reiterating a pledge made in Copenhagen, developed countries committed to providing $US30 billion of new and additional resources for the period 2010-2012, with a balanced allocation between adaptation and mitigation. The Cancun Agreements invite developed countries to submit information on how they are meeting this ‘fast-start finance’ commitment by May 2011, 2012, and 2013.It is important to note, however, that the Cancun Agreements contain no specifics with regard to the format that such reporting should follow, putting the quality of these reports at risk. That is why WRI has issued a list of elements we hope to see in these reports.What new institutions were created in Cancun that relate to the MRV of finance?The Cancun Agreements established a “Green Climate Fund,” to channel financial resources to developing countries. A Standing Committee was also established to improve coordination in the delivery and MRV of climate finance.In addition to these bodies under the financial mechanism, the Cancun Agreements established a registry that will help developing countries match their projects with available international support.What are the next steps in this process?The Parties to the UNFCCC have a great deal of work to do in the months leading up to the next Conference of the Parties in Durban in December 2011 in order to improve the transparency of climate finance.Countries will need to draft enhanced guidelines and methodologies for reporting climate finance, as well as review procedures. This should include an agreed common approach for reporting on additionality, which was not addressed in Cancun.In the meantime, developed countries will need to report on their fast-start financial commitments starting this year each May until 2013.In addition, countries will need to clarify the role of the Standing Committee, particularly in relation to the MRV of finance process.Finally, many of the characteristics of the registry have yet to be determined. This includes the role, if any, the registry or another other international body will play in reviewing the actions and support submitted to the registry.last_img read more

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Man United hold out for draw at Sevilla

first_imgSevilla 0 Manchester United 0: De Gea ensures Mourinho’s men stay level Ryan Benson Last updated 1 year ago 05:38 22/2/2018 pogba-cropped Getty Images Sevilla were unable to make their dominance tell as Manchester United left the Ramon Sanchez Pizjuan with a 0-0 draw. Manchester United survived plenty of pressure to claim a 0-0 draw at Sevilla in the first leg of their Champions league last-16 clash, owing particular thanks to an immense David de Gea save at the end of the first half.Sevilla controlled proceedings for much of the game and, although they generally struggled to craft clear-cut chances, Luis Muriel saw their best denied in stunning fashion by De Gea as United battled to return home with honours even.The pre-match debate surrounding Jose Mourinho’s decision to drop Paul Pogba took on a new dimension after just 17 minutes when the Frenchman replaced the injured Ander Herrera, though he was unable to flourish as Sevilla dominated. Article continues below Editors’ Picks Williams case shows Solskjaer isn’t holding Man Utd’s youngsters back – he’s protecting them Goalkeeper crisis! Walker to the rescue but City sweating on Ederson injury ahead of Liverpool clash Out of his depth! Emery on borrowed time after another abysmal Arsenal display Diving, tactical fouls & the emerging war of words between Guardiola & Klopp United had to rely on the heroics of De Gea to keep them on level terms at the break, with the Spain international denying both Gabriel Mercado and Muriel late on – the Colombian drawing a remarkable save from the former Atletico Madrid star. The second half was similarly frustrating for the home side and United began to see more of the ball after the hour as the contest opened up.But ultimately neither team could find a way through, with Pablo Sarabia wasting a good chance for Sevilla late on, giving Vincenzo Montella’s men work to do in the return leg at Old Trafford on March 13.FT – Sevilla 0 #MUFC 0.It ends all square in southern Spain. pic.twitter.com/eQIIdeXRdn— Manchester United (@ManUtd) February 21, 2018Full of attacking intent and purposeful going forward, Sevilla established early control and played some eye-catching football.Goalscoring opportunities were not exactly a regular occurrence, but Muriel forced De Gea into a fine stop from distance in the fourth minute and Jesus Navas shot just wide of the bottom-left corner from a similar distance a few moments later.Pogba was then handed his chance of a reprieve, replacing the stricken Herrera, and United appeared to become more stable in midfield as a result.Their first chance came soon after, but Romelu Lukaku blasted his volley well over from just inside the area following Alexis Sanchez’s excellent lofted pass.The visitors were fortunate to still be on level terms at half-time, though.De Gea rescued United twice right at the end of the half, tipping Mercado’s header over before then producing an excellent save to deny Muriel’s nodded effort.The definition of respect.Stalemate. #ThisIsSevilla #SevillaFamily pic.twitter.com/i4eOdWl3ob— Sevilla FC (@SevillaFC_ENG) February 21, 2018Sevilla remained dominant at the start of the second half, but their inability to craft clear-cut chances blighted their play, seeming to run out of ideas once in the final third.Muriel summed up Sevilla’s frustrations just before the hour mark, dragging a left-footed effort wide of the right-hand post.De Gea was eventually called into action again in the 64th minute, but he had little difficulty getting down to keep Clement Lenglet’s header.The United goalkeeper was helpless 15 minutes from time, but Sarabia headed over from close range following Muriel’s right-wing cross.That proved to be the final chance and it will be United who look ahead to the second leg with the greater satisfaction, having emerged from a tough contest with no damage done. Key Opta facts:- Five of Manchester United’s last seven Champions League away matches in Spain have ended goalless.- This was Manchester United’s ninth clean sheet in their last 11 matches in all competitions and their 23rd in all competitions this season – three more than any other Premier League side.- United have drawn 22 matches in the Champions League goalless, a record they share with AC Milan.- Sevilla failed to score in a home Champions League game for the first time – this was their 19th home match in the competition.- Only Aleksandar Kolarov (nine times v FK Qarabag in September) has been fouled more in a Champions League game this season than Alexis Sanchez in this match (6).- Scott McTominay became the fourth youngest Englishman to start a Champions League knockout match for the Red Devils – only Wayne Rooney, Phil Neville and Phil Jones were younger. read morelast_img read more

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‘Barca game Atleti’s only chance in La Liga’

first_imgAtlético Madrid ‘Barcelona game Atletico’s only chance to close La Liga gap’ Manasi Pathak 19:39 2/3/2018 FacebookTwitterRedditcopy Comments(1) Antoine Griezmann Atletico Madrid Getty Atlético Madrid Primera División Barcelona v Atlético Madrid Barcelona Gaizka Mendieta, formerly of Barcelona, insists that Diego SImeone’s men must win if they are to have any chance of winning the title Atletico Madrid’s encounter with Barcelona represents their only chance to reel in the La Liga leaders, according to former Barca midfielder Gaizka Mendieta.Atleti are five points behind Lionel Messi et al after Barca were held to a 1-1 draw by Las Palmas on Thursday.The two sides will clash this weekend at Camp Nou, with Atleti looking to extend an eight-game unbeaten streak in all competitions. Article continues below Editors’ Picks Williams case shows Solskjaer isn’t holding Man Utd’s youngsters back – he’s protecting them Goalkeeper crisis! Walker to the rescue but City sweating on Ederson injury ahead of Liverpool clash Out of his depth! Emery on borrowed time after another abysmal Arsenal display Diving, tactical fouls & the emerging war of words between Guardiola & Klopp And Mendieta believes the game offers perhaps Atleti’s only chance to close the gap as the season progresses.”It will be a tough game. For Atletico Madrid, it will be about cutting off the points gap, while for Barcelona it will be to keep the distance at the top of the table because the end of the season will be really tough in terms of the title challenge,” he told Goal in an exclusive interview.”Atleti will have this match as the only chance to get closer to Barcelona.”Mendieta spent a solitary season on loan at Barca, but is perhaps best known for his spell at Valencia, where he won the Copa del Rey and the Supercopa de Espana, while he also reached two Champions League finals.Valencia are currently fourth in La Liga, just one point behind Real Madrid, and Mendieta has been impressed with the current crop of players.He said: “I think the performance of Valencia so far has been great. Considering the past few seasons, it has been really good.”What started as a new project, under a new manager and a bit of expectation, it has been amazing. Now, hopefully, Valencia qualify for the Champions League.”MendietaValencia have a remarkable track record of producing major stars, including the likes of David Silva and Paco Alcacer, and gave a debut to talented right winger Ferran Torres earlier this season, with the 18-year-old recording his first assist in the 1-1 draw with Athletic Bilbao.Mendieta added: “Valencia has always had a great academy. The way they project their youngsters into the first team is great. Ferran Torres is another talented youngster who has come through the academy.”Valencia has always been a club which has broken young talent through the ranks and sold them. This has been their philosophy all these years; it’s great to see them produce great players.”Gaizka Mendieta is in India as La Liga’s ambassador.  La Liga has a following of over 37 million over the globe. Join the conversation at Facebook.com/LaLigalast_img read more

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Blog Guest Stars on the Elements of Persuasion

first_imgKatya’s note: Pictured here are Robert Dickman (left) and Richard Maxwell (right), the authors of a new book called The Elements of Persuasion. This book, which helps you use storytelling to do all of your work better, is a favorite of mine. I liked it so much that I cited it heavily in Network for Good’s recent Nonprofit 911 Call on Storytelling, which you can listen to for free here. I invited the The Elements of Persuasion co-authors to do a guest post here at my blog talking about how their book can help nonprofits, and they not only agreed, they’ve done TWO guest posts. Very nice! So enjoy this first segment today – the second will run tomorrow. They are also bloggers, so be sure to check out their regular musings here.As important as having the right story is to any organization, it is even more important in the not for profit arena. There are lots of reasons for this. Turning people on to your issue requires a great elevator pitch that doesn’t seem like one because you never know when you will run into a good volunteer or a donor ready to give. A good story helps people see that your issue is their issue too. And word of mouth is both the cheapest way to get your message out and the most persuasive form of fund raising. The right story, well told can make all the difference. In our book The Elements of Persuasion we define a story as “a fact wrapped in an emotion that compels us to take an action that transforms our world.” A good story needs to be both emotional and truthful to work. To be a great story it needs to use what we have identified as the Five Story Elements. Every successful story has all five – the PASSION with which the story is told, a HERO who provides the listener with a point of view to enter the story and see it as their own, an ANTAGONIST or problem that the Hero must overcome, a moment of AWARENESS that allows the Hero to prevail, and the TRANSFORMATION that results in the world. To find out more about these elements operate, you can read the first chapter here. It’s free.Tomorrow: How you, the nonprofit, can use each of these five elements.last_img read more

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Good advice in a fundraiser’s story

first_imgSome weeks ago, after a speech I gave in North Carolina, Robyn Fehrman came up to me and told me about how she spends her free time. By day, Robyn is a program officer at the Triangle Community Foundation. But in her spare time, she volunteers to raise awareness about homelessness in Durham, NC and raise funds for Genesis Home (a transitional shelter for homeless families with children) through the Tri to End Homelessness campaign. For ten months, she’s been tirelessly raising thousands of dollars with her sister for the cause. I’m thankful there are people like Robyn in the world.Here’s her story:As triathletes and community advocates, my sister Rachel Dirito and I dedicated our 2007 triathlon season to supporting Genesis Home and speaking out. We documented our year on our blog and raised nearly $6,000 – $4,000 of which was matched by a local private foundation. In March, we specifically mentioned Network for Good’s 6 Degrees program in our post. Since I’m a big advocate of getting people like Robyn behind your cause, I asked her to share some advice about how she became an effective superactivist. Here’s her story — and her advice. Wouldn’t you know, it’s the same basic stuff that works so well. Keep these basics in mind as you head into the final stretch of fundraising season 2007. We forget them too often!Robyn says:We found success in the old stand-bys of (1) Asking for money! (2) Thanking donors promptly with handwritten thank you notes and (3) Letting donors know how their money has been used. We also communicated a lot. We recommend that you:1. Use Many Channels: Create buzz by telling your story through multiple “genres.” The Tri to End Homelessness campaign was anchored at our BLOG; however, we also EMAILED friends and family, wore BUTTONS that said “Ask Me About Genesis Home” during training runs/ rides and at races throughout the year, wrote a story for Genesis Home’s NEWSLETTER, met IN PERSON with folks, and sent in stories to LOCAL NEWSPAPERS & MAGAZINES.2. Help folks find a personal connection to your issue. For many folks, homelessness is something they would rather just not think about or something that they have a hard time connecting with. We became that connection through telling our own personal stories about why this issue was important to us. 3. Update folks about your goals. Having a blog helped us stay in touch with our donors/ audience and allowed us to regularly update them on both our fundraising and triathlon goals. These regular updates helped to cultivate ongoing connection. So listen to Robyn – don’t forget to ask, thank and show. And communicate often, in many ways.In honor of her cause, I’m posting this video:last_img read more

Category Archives: iompaedb

Whats in a name 5G wireless claims but no real network

first_imgNEW YORK — AT&T has drawn ridicule by relabeling the network used by some of its phones as “5G E” to signal that the next-generation wireless network is here.Problem is, phones capable of connecting to 5G aren’t coming for another few months, and a national 5G network won’t be deployed until 2020 or 2021.But Verizon, which complained Tuesday about AT&T’s move, did something similar when it launched a residential wireless service with the 5G moniker using its own proprietary standards.A new generation of wireless network comes along every several years, so the stakes are high for carriers to establish their dominance. When it’s fully deployed, the “5G” network is expected to give mobile users faster speeds for video, self-driving cars and connected devices at home.Mae Anderson, The Associated Presslast_img read more

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Enbridge backers Cenovus Suncor to make their case for Northern Gateway

TERRACE, B.C. — The panel weighing the future of the Northern Gateway pipeline will hear today from industry players who support the project.The Canadian Association of Petroleum Producers and Enbridge’s partners in the project, including Cenovus  and Suncor Energy, are scheduled to make their final arguments to the federal panel hearing in Terrace, B.C.A B.C. government lawyer addressed the panel on Monday, saying the project should not be approved as proposed.“Given the unique challenges of this pipeline, including the real challenges of responding effectively to a spill from either the pipeline or a tanker, Northern Gateway must be able to show that the mitigation it has put forward will be effective,” Christopher Jones told the panel.“The province submits it has not done so.”Outside the hearings, former B.C. Liberal cabinet minister Geoff Plant, who is leading B.C.’s legal team at the hearings, said the evidence put before the panel doesn’t meet the province’s standards.“Northern Gateway is going to have to do something more, something better, somewhere else, to do that,” he said.Plant said the province is asking that the project not receive approval, but it has put forth several conditions should the panel decide to give it a green light.For its part, a lawyer for the company told the panel it agreed with most of those conditions.“I do think it’s good that there’s some congruity on the general conditions. It shows that Northern Gateway is currently trying to raise the bar, and willing to meet a high bar, even though we don’t think that they’re there yet,” Plant said.Northern Gateway lawyer Richard Neufeld told the panel the project is worth billions of dollars and is in the interest of all Canadians.As for the province’s concerns about the lack of proof that the company’s spill response will be all that is promised, he said detailed operational plans are unnecessary and counter-productive at this point in the process.The pipeline, if approved, wouldn’t be operational until 2018, Neufeld told the panel.“There was and there remains ample time to develop detailed operational-response plans that will be second to none,” he said.“This is not a case of putting off until tomorrow what you can do today. It’s a case of developing operational plans in an orderly, organized manner … This is an ongoing process.”Dozens of opponents and supporters of the project are scheduled to appear over the next two weeks. read more

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Rogers Media agrees to pay 200000 fine under CRTCs antispam law

Rogers Media has agreed to pay a $200,000 fine to the CRTC for allegedly sending unsolicited email advertisements.The fine was levied under anti-spam legislation which took effect last year.The CRTC says the apparent violations stretched from July 2014 to July 2015 when consumers found emails came with an “unsubscribe” option that wouldn’t function properly.Allegations by the regulator also say Rogers Media, a division of Rogers Communications, failed to honour unsubscribe requests from recipients within 10 business days.Porter Airlines fined $150,000 for violating anti-spam law, CRTC saysStill getting spam emails? You’re not aloneThis corporate training firm from Quebec may have to pay $1.1 million for violating Canada’s anti-spam lawIt is the fourth fine under the new anti-spam laws this year.Corporate training company Compu-Finder was the first — fined $1.1 million in March. Since then, online dating website PlentyOfFish and Porter Airlines, have faced smaller fines of $48,000 and $150,000 respectively.Under the anti-spam law, the first unsolicited email sent by a Canadian company is considered a violation.Canadians will be able to file lawsuits against businesses for breaking the anti-spam laws once a transition period ends on July 1, 2017, the CRTC said. read more

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Changes at BlackBerry in Waterloo

00:00:00 | 00:00:00::Projekktor V1.3.09 BlackBerry, once the undisputed leader in the smartphone market, has cut another 100 jobs in Waterloo, as the company continues to downsize.  Kelda Yuen spoke to residents and entrepreneurs in Kitchener-Waterloo Tuesday about how the tech giant’s recent troubles are affecting the region.

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WatchMajority of firsttime buyers maxed out budgets to buy a home CMHC

Laura Pedersen/National Post files TORONTO — The country’s real estate market may be taking a breather, but a new survey suggests the vast majority of recent homebuyers are maxing out their budgets to purchase their first homes.In its annual mortgage consumer study, Canada Mortgage and Housing Corp. found that 85 per cent of first-time buyers reported spending the most they could afford on their property.Despite this, 76 per cent say they were still confident that they would be able to make their monthly mortgage payments.Condo flipping was never the culprit behind Vancouver and Toronto’s home price spikesBaby boomers plan to stay in their homes, renovate in face of unaffordable housing marketsThe cost of owning a home in Vancouver (88% of income) has hit crisis levelsSixty per cent of first-timers and 69 per cent of repeat buyers reported having “sufficient assets” such as investments or other properties to help them if they were to run into financial trouble with their mortgage.The federal housing agency, which has been conducting the survey since 1999, says housing affordability continues to be the most important factor cited among first-time and repeat homebuyers, when compared to other factors such as a property’s neighbourhood, proximity to work and condition.CMHC says housing affordability continues to be the most important factor among first-time homebuyers. More than half of those concerned say their top worries included unforeseen costs, paying too much for their home and rising interest rates.The Bank of Canada has raised its key interest rate target four times to 1.5 per cent since July 2017. It is widely anticipated that the central bank will announce another hike at its next meeting on Oct. 24.Some housing markets across the country have already been feeling the cooling effects of higher interest rates coupled with some recently introduced measures like the new mortgage stress test and a 15 per cent foreign buyer tax in Ontario.Earlier this week, the Canadian Real Estate Association reported that national home sales fell for the first time in five months in September amid weakening markets in Vancouver and Toronto.Despite prices also flattening, the outlook on the national real estate market remains positive.The CMHC survey found that 80 per cent of homebuyers polled still believe that buying property is a good long-term financial investment. Sixty-six per cent believed their home value would increase within the next 12 months.The online survey, which was conducted in April, polled more than 4,000 Canadians who became mortgage consumers in the last year.The polling industry’s professional body, the Marketing Research and Intelligence Association, says online surveys cannot be assigned a margin of error as they are not a random sample and therefore are not necessarily representative of the whole population. read more

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Yellow fever deaths increase in Brazil

SAO PAULO, Brazil (AP) — Brazil’s health ministry says 1,257 cases of yellow fever have been registered in Latin America’s biggest country between July 1, 2017 and May 2, 2018. Of those, 394 have died.The data was released on Friday.In its previous report, the Health Ministry said 1,157 cases of the mosquito-borne disease and 342 deaths had been confirmed through April 17.The ministry said it plans to vaccinate nearly 80 million people against yellow fever by April 2019. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)RelatedYellow fever vaccine shortage affecting travel- RamsammyFebruary 25, 2017In “Opinion”Mosquito-borne virus Zika threatens CaribbeanMay 19, 2015In “Business”Grenada placed on dengue alertJanuary 11, 2019In “Health” read more

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Permanent TSB looks to raise €500 million for mortgage lending

first_imgPERMANENT TSB WILL attempt to defy the stagnant Irish mortgage market next week and raise up to €500 million that would be used for new lending.The move will be the first mortgage-backed transaction for an Irish bank since the bank guarantee and will see PTSB form a new Residential Mortgage-Backed Security (RMBS).The security, which will be backed by the bank’s most secure mortgages, will be marketed by US firm Morgan Stanley. None of the mortgages are in arrears of over 30 days.The plan has surprised some analysts, who say that if successful it would open up new investors into Irish banks.The selling of securities became controversial after the banking collapse of 2008, but industry insiders say it is the best way to fund a mortgage market.This week it was warned that Ireland’s three state-backed banks could lose over €150 million after the ECB cut tracker mortgage rates.Read: Nobel economist says Ireland is looking at a “lost decade” after austerityRead: RSA Insurance executives suspended as firm announces €84m profit shortfalllast_img read more

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Bowling Video Game Controlled By Kissing

first_imgI suppose that bowling made sense for the demo. The gameplay is simple and short, so you don’t have to do it for too long–can you image trying to beat Donkey Kong with the thing? You’d definitely start chaffing. In his mission to make bowling video games more exciting (or, perhaps, to make intimacy less appealing), artist Hye Yeon Nam if offering the world the latest innovation in gaming peripherals–the Kiss Controller. To start playing, grab  partner, and shove your tongue down their throat.Here’s the breakdown from Nam, One person has a magnet on his/her tongue and the other person wears the headset. While they kiss, the person who has the magnet on his/her tongue, controls the direction and speed of the bowling ball for 20 seconds. The goals of this game are to guide the ball so that it maintains an average position in the center of the alley and to increase the speed of the ball by moving the tongue faster while kissinglast_img read more

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iPad 3 will reportedly have 8MP rear camera HD Facetime

first_imgAs we rapidly approach Apple’s iPad 3 announcement (likely within the next two to three months), it’s expected that the rumor mill will heat up. Some will be accurate, many will be off, and others will be on the opposite side of the universe. Only hindsight will tell us which are which, so let the guessing games commence. The latest story has the next-gen tablet getting cameras that match the iPhone 4S’s 8MP shooter.Such a camera upgrade would be an enormous improvement. Apple went cheap with the iPad 2’s cameras, and it shows. The sub-1MP rear shooter harkens back to the days of 2005 camera flip phones, which you would only dream of using if it were the only camera in sight. The iPad 3’s front camera would also supposedly get an upgrade. It’s said to shoot HD video, allowing for much crisper-looking Facetime calls (particularly for recipients on large-screen devices).The story, however, didn’t stop with cameras. It says that the next iPad will get an A6 processor (no surprise), a Retina display (also expected), and would be slightly thicker than the iPad 2 to help power that Retina display. Its curves would also be slightly more rounded to compensate for the minor added thickness. The story also says that the previous rumor of the iPad 3 arriving in January (on Steve Jobs’s birthday) is bogus, as this would peeve holiday shoppers who just threw down for an iPad 2. We can expect the iPad 3 at about the same time that we saw the iPad 2 last year (March 11).One last detail is that the price of the iPad 2 will allegedly be dropping — perhaps to $400 — in order to help combat budget tablets like the Kindle Fire. As this is the same strategy that Apple has used for the last several years with iPhones, this would hardly be a surprise. The iPad 2 would still be $200 more than the Fire, but it creeps just close enough to help sway some cost-cutting customers.Does this report have legs? Only time will tell. What we can guarantee is that we’ll be hearing many more of these rumors during the next couple of months.via iLoungelast_img read more

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